Top 20 US Stocks in Trading Volume: Lilly slimming pills approved, with stock price reaching a historic high. 6th place Lilly closed up 3.2%, with stock price reaching a historic high, with a transaction volume of $4.736 billion. On Wednesday (November 8th) local time, the US Food and Drug Administration (FDA) announced on its official website that it has approved Lilly's Tirzepatide injection for long-term weight management under the trade name "Zepbound".