Accelerating the Internationalization Strategy to Promote the Cooperation between Hengrui Pharmaceuticals and German Merck
阿豆学长长ov
发表于 2023-11-2 12:14:50
252
0
0
On October 30th, Jiangsu Hengrui Pharmaceutical Co., Ltd. (hereinafter referred to as "Hengrui Pharmaceutical", 600276. SH) announced that it had reached an agreement with German Merck. Hengrui Pharmaceuticals will license the Class 1 new drug HRS-1167 tablets (hereinafter referred to as "HRS-1167") with independent intellectual property rights and the injection SHR-A1904 (hereinafter referred to as "SHR-A1904") project to Merck for a fee.
It is reported that this is the first time Hengrui Pharmaceutical has reached strategic cooperation with a large multinational enterprise worldwide.
Dr. Jiang Ningjun, Director and Chief Strategic Officer of Hengrui Pharmaceutical, stated that, There is still a huge unmet clinical demand for cancer treatment globally. We are very pleased to work together with Merck to bring Hengrui innovative drugs to the world and benefit cancer patients worldwide. This time, we are working with Merck on PARP (Poly Adenosine Diphosphate Ribose Polymerase) The authorized cooperation in the field of inhibitors is an important milestone in the development of Hengrui's internationalization strategy. We look forward to accelerating research and development to drive innovation, bringing better treatment options to patients who have long faced treatment difficulties
Strong cooperation
It is reported that HRS-1167 is a selective, highly active, and oral PARP1 small molecule inhibitor independently developed by Hengrui Pharmaceutical and has intellectual property rights. It belongs to the second generation of PARP inhibitors. HRS-1167 is currently in the early clinical development stage and has the potential to treat more patients as a monotherapy and combination therapy.
SHR-A1904 is an antibody drug conjugate (ADC) independently developed by Hengrui Pharmaceutical and has intellectual property rights targeting Claudin 18.2. By binding to the target antigen on the surface of tumor cells, the drug is internalized and released into cells, releasing small molecule toxins to kill tumor cells. This product is currently undergoing phase I clinical trials in China, the United States, and Australia. Currently, there are no Claudin 18.2 ADC products approved for launch globally.
According to the agreement, Merck will obtain the exclusive right of HRS-1167 to develop, produce and commercialize in the world outside Chinese Mainland, the exclusive right of SHR-A1904 to develop, produce and commercialize in the world outside Chinese Mainland, and the option of HRS-1167 and SHR-A1904 to jointly commercialize with Hengrui Pharmaceutical in Chinese Mainland.
According to the terms of the agreement, Hengrui Pharmaceutical will receive a down payment of 160 million euros, a technology transfer fee and exercise fee of up to 90 million euros, as well as research and development milestone payments and sales milestone payments. The total potential payment amount mentioned above may reach up to 1.4 billion euros. In addition, Merck will also pay sales commissions of up to double-digit percentages to Hengrui Pharmaceutical.
According to Cortellis, nearly 10 companies worldwide are currently developing second-generation PARP inhibitors, ranging from preclinical to early clinical stages.
Hengrui Pharmaceuticals' HRS-1167 started its Phase I clinical trial in August 2022, only lagging behind AstraZeneca's AZD5305 and Nerviano Medical Sciences/Merck KGaA's NMS-293 in terms of progress, and is in the top three globally, comparable to AstraZeneca's other second-generation PARP inhibitor AZD9574.
This collaboration with Hengrui Pharmaceuticals has enriched our product pipeline in areas such as DNA damage response inhibition and ADC drugs, in line with Merck's expectations for external innovation and internal research and development strategies in the field of tumors. "said Danny Bar Zohar, Global R&D Director and Chief Medical Officer of Merck Healthcare, The synergy between them and our product portfolio has broad development potential, providing more treatment options for patients with refractory tumors. We look forward to fully leveraging Hengrui Pharmaceutical's rich professional knowledge, strengthening cooperation, and moving forward together
Internationalization acceleration
In the third quarter of this year, Hengrui Pharmaceutical's operating revenue was 5.845 billion yuan, a year-on-year increase of 2.24%; The net profit attributable to shareholders of the listed company was 1.166 billion yuan, a year-on-year increase of 10.57%. In the first three quarters of this year, Hengrui Pharmaceutical's operating revenue and net profit were 17.014 billion yuan and 3.474 billion yuan, respectively, with year-on-year growth of 6.7% and 9.47%.
In terms of innovative research and development, Hengrui Pharmaceutical continues to maintain a high level of investment. In the first three quarters, Hengrui Pharmaceutical's research and development expenses were 3.725 billion yuan, a year-on-year increase of 6.52%.
It is understood that in the second half of this year, Hengrui Pharmaceutical has authorized multiple overseas cooperation projects, demonstrating Hengrui Pharmaceutical's strong innovative drug research and development capabilities and its international strategic achievements.
On August 14th, Hengrui Pharmaceuticals announced an agreement with One Bio, Inc. in the United States to license the Class 1 new drug SHR-1905 injection project with independent intellectual property rights to One Bio, Inc. in the United States for a fee. According to the relevant agreement, the down payment and recent milestones amount to $25 million. In addition, based on the initial approval and actual annual net sales of SHR-1905 in the United States, Japan, and agreed European countries, One Bio will pay Hengrui Pharmaceutical a cumulative milestone payment of no more than $1.025 billion for research and sales.
On October 8th, Hengrui Pharmaceuticals announced an agreement with Dr. Reddy's laboratory in India to license the targeted drug pyrrolitinib maleate tablets project with independent intellectual property rights to Dr. for a fee Reddy's, the company will receive a down payment of $3 million and a maximum sales milestone payment of $152.5 million.
On October 17th, Hengrui Pharmaceuticals announced that it will license the Class 1 new drug injection Karelizumab project with independent intellectual property rights to Elevar Therapeutics in the United States for a fee. Elevar Therapeutics will have the exclusive right to develop and commercialize the combination therapy of Carelizumab and Antibiotic in the treatment of hepatocellular carcinoma worldwide, except for Greater China and South Korea. Hengrui Pharmaceutical is expected to receive a cumulative sales milestone payment of $600 million and subsequent additional payments, as well as a sales commission of 20.5% of actual annual net sales.
CandyLake.com 系信息发布平台,仅提供信息存储空间服务。
声明:该文观点仅代表作者本人,本文不代表CandyLake.com立场,且不构成建议,请谨慎对待。
声明:该文观点仅代表作者本人,本文不代表CandyLake.com立场,且不构成建议,请谨慎对待。
猜你喜欢
- GLP-1 Weight Loss Drug Production Capacity Warming Up: Lilly builds a factory in Germany for $2.5 billion and is expected to operate in 2027
- NIO and GAC Group's strategic cooperation agreement on charging and swapping
- SAP and Tang Renshen sign a strategic cooperation agreement
- IBM announces its "open source" strategy: releasing Granite series models to focus on code generation
- Baozun E-commerce responds to Alibaba's clearance: normal trading behavior after investment strategy adjustment
- Cleared by Alibaba! Baozun E-commerce Response: Understand its normal trading behavior after adjusting its investment strategy
- OpenAI claims that its strategic cloud relationship with Microsoft has not changed
- Upgrade the "New Fortress" of Ping An Family Medicine's Ping An Support Strategy for Growth
- Faraday Future: Pushing forward new car delivery, continuing to seek strategic financing and striving to attract strategic investors in the Middle East region
- Faraday Future: FF is pushing for new car delivery, continuing to seek strategic financing and striving to attract strategic investors in the Middle East region
-
理想自動車官博によると、2024年6月、理想自動車が新車47774台を納入し、前年同期比46.7%増となった。2024年第2四半期に108,581台が納入され、前年同期比25.5%増加した。2024年6月30日現在、理想自動車の累計納入台 ...
- 寒郁轩良
- 昨天 17:19
- 支持
- 反对
- 回复
- 收藏
-
【スタンダード500指数が今年31回の高値を迎えるにあたり、ゴールドマン・サックスは今こそ「ブレーキを踏む」ことができると警告した!】今年、大手科学技術株がスタンダード500指数の強力な反発を後押しし、一連 ...
- 愿为素心人
- 3 天前
- 支持
- 反对
- 回复
- 收藏
-
最新の財報は市場予想を下回り、ナイキは急落した。 現地時間6月28日金曜日、米株3大株価指数が集団で下落した。終値まで、ダウ平均は0.12%、ナ指は0.71%、スタンダード500指数は0.41%下落した。 経済データについ ...
- hecgdge4
- 3 天前
- 支持
- 反对
- 回复
- 收藏
-
6月30日、Kindle中国電子書店はダウンロードサービスを停止し、ホット検索に突入した。 アマゾンの中国公式サイトによると、2024年6月30日からKindle中国電子書店はクラウドダウンロードサービスを停止し、その後ダ ...
- 什么大师特
- 昨天 09:21
- 支持
- 反对
- 回复
- 收藏